Phentermine Side Effects, Drug Interactions, and Safety Guidelines

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While Phentermine is effective for short-term weight management, it carries potential side effects and health precautions that require medical monitoring. Common side effects include dry mouth (xerostomia), insomnia, restlessness, elevated heart rate (tachycardia), increased blood pressure, and gastrointestinal disturbances. Serious risks include primary pulmonary hypertension and valvular heart disease, particularly if combined with unapproved weight loss agents. Phentermine is contraindicated in patients with a history of cardiovascular disease, hyperthyroidism, glaucoma, agitated states, or substance use disorder, as well as those currently taking or within 14 days of taking monoamine oxidase inhibitors (MAOIs).